Tissue Engineering Institute for Growth Factor

Tissue Engineering Institute for Growth Factors

It is the goal of COWELLMEDI Tissue Engineering Institute for Growth Factors
to develop technology that can completely restore the
nature-look gingiva.

As the first South Korean Dental Implant enterprise that grafted Recombinant Human Bone
Morphogenetic Protein(rhBMP-2) to dental implant, COWELLMEDI has been leading the era
of next-generation bio-convergence implants.

  • 양질의 뼈 재생
  • 세균 감염 방지
  • 안정성 입증

What is COWELLMEDI rhBMP-2?Recombinant Human Bone Morphogenetic Protein-2

What happens when the stem cells and BMP-2 are combined?


BMP-2 is human growth factor(protein) which pediatric can self-produce but adults are disabled to produce by themselves.
Therefore, when genetically engineered rhBMP-2 is injected into defective gingiva tissue and bone,
it simulates stem cells in the body and quickly grows into bone and gum tissue.

The procedure of rhBMP-2 growth factor how to grow into bone

  • Stem cells BMP-2 attached
    grows into bone cells.
  • BMP-2 attached stem cells
    grows into bone cells.
  • Nutrition and blood vessels are
    formed for bone regeneration.
  • The strong bone
    tissue is formed.

Research papers on CowellBMP

  • Effects of rhBMP-2 coating Tricalcium phosphate on socket preservation in dog extraction socket Tissue Engineering and regenerative Medicine V5,No4~6 (2008)
  • Effects of polycaprolactone-Tricalcium phosphate, recombinant Human Bone Morphogenetic Protein-2 and
    Dog Mesenchymal stem cells on bone formation: pilot study in dogs
    Yonsei Med J 50(6), 2009
  • Alveolar ridge augmentation using anodized implants coated with E coli –derived recombinant human bone
    morphogenetic protein-2
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(1),2011
  • The induction of bone formation in rat calvarial defects and subcutaneous tissue by recombinant human
    BMP-2, produced in Escherichia coli
    Biomaterials 31, 2010
  • Induction of bone formation by Escherichia coli-expressed recombinant human bone morphogenetic
    protein-2 using block-type macrophorous biphasic calcium phosphate in orthotopic and ectopic rat model
    J periodontol Res2011
  • Morphometric analysis on bone formation effect of β-TCP and rhBMP-2 in rabbit mandible J Korean Assoc Oral Maxillofac Surg (2010)
  • Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011)
  • Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia
    coli–erived recombinant human bone morphogenetic protein 2 in rat calvarial
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011)
  • Analysis of hydrolyzable polyethylene glycol hydrogels and deproteinized bone mineral as delivery
    systems for glycosylated and non-glycosylated bone morphogenetic protein-2
    Acta Biomaterialia (2011)
  • Enhanced adipogenic differentiation and reduced collagen synthesis induced by human periodontal
    ligament stem cells might underlie the negative effect of recombinant human bone morphogenetic
    protein-2 on periodontal regeneration
    J Periodont Res (2011)