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R&D

Dental Implant Laboratory

It is the goal of COWELLMEDI Dental Implant Laboratory
to develop technology that can completely restore the nature-look teeth.

COWELLMEDI Dental Implant Laboratory, which has been in the center of COWELLMEDI R&D endeavors,
established in 2004 and has been constantly challenging itself to develop optimal Dental Implant that
meets the diverse implant placement requirements based on its excellent staffs and equipment.

  • 친수성 증대
  • 골유착 가속화
  • 안정성 입증

Tissue Engineering Institute for Growth Factors

It is the goal of COWELLMEDI Tissue Engineering Institute for Growth Factors
to develop technology that can completely restore the
nature-look gingiva.

As the first South Korean Dental Implant enterprise that grafted Recombinant Human Bone
Morphogenetic Protein(rhBMP-2) to dental implant, COWELLMEDI has been leading the era
of next-generation bio-convergence implants.

  • 양질의 뼈 재생
  • 세균 감염 방지
  • 안정성 입증

What is COWELLMEDI rhBMP-2?Recombinant Human Bone Morphogenetic Protein-2

What happens when the stem cells and BMP-2 are combined?

Osteoinductive

BMP-2 is human growth factor(protein) which pediatric can self-produce but adults are disabled to produce by themselves.
Therefore, when genetically engineered rhBMP-2 is injected into defective gingiva tissue and bone,
it simulates stem cells in the body and quickly grows into bone and gum tissue.

The procedure of rhBMP-2 growth factor how to grow into bone

  • Stem cells BMP-2 attached
    grows into bone cells.
  • BMP-2 attached stem cells
    grows into bone cells.
  • Nutrition and blood vessels are
    formed for bone regeneration.
  • The strong bone
    tissue is formed.

Research papers on CowellBMP

  • Effects of rhBMP-2 coating Tricalcium phosphate on socket preservation in dog extraction socket Tissue Engineering and regenerative Medicine V5,No4~6 (2008)
  • Effects of polycaprolactone-Tricalcium phosphate, recombinant Human Bone Morphogenetic Protein-2 and
    Dog Mesenchymal stem cells on bone formation: pilot study in dogs
    Yonsei Med J 50(6), 2009
  • Alveolar ridge augmentation using anodized implants coated with E coli –derived recombinant human bone
    morphogenetic protein-2
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(1),2011
  • The induction of bone formation in rat calvarial defects and subcutaneous tissue by recombinant human
    BMP-2, produced in Escherichia coli
    Biomaterials 31, 2010
  • Induction of bone formation by Escherichia coli-expressed recombinant human bone morphogenetic
    protein-2 using block-type macrophorous biphasic calcium phosphate in orthotopic and ectopic rat model
    J periodontol Res2011
  • Morphometric analysis on bone formation effect of β-TCP and rhBMP-2 in rabbit mandible J Korean Assoc Oral Maxillofac Surg (2010)
  • Bone formation of Escherichia coli expressed rhBMP-2 on absorbable collagen block in rat calvarial
    defects
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011)
  • Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia
    coli–erived recombinant human bone morphogenetic protein 2 in rat calvarial
    defects.
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011)
  • Analysis of hydrolyzable polyethylene glycol hydrogels and deproteinized bone mineral as delivery
    systems for glycosylated and non-glycosylated bone morphogenetic protein-2
    Acta Biomaterialia (2011)
  • Enhanced adipogenic differentiation and reduced collagen synthesis induced by human periodontal
    ligament stem cells might underlie the negative effect of recombinant human bone morphogenetic
    protein-2 on periodontal regeneration
    J Periodont Res (2011)