Cowell® BMPOsteoinductive Bone Graft , rhBMP-2 + BCP

Composition of COWELL® BMP

  • COWELL® BMP is a bone graft material based on the E.rhBMP-2 (E.Coli derived Recombinant Human Bone Morphogenetic Protein type 2), developed for the first time in the world. COWELL® BMP is supported with 10 years of clinical data and over 40 studies.
  • BCP as a carrier allows maintenance of space.

Features of COWELL® BMP Bone Graft

  • Primary closure for soft tissue regeneration is not required.
  • Regenerates adherent gingiva.
  • Simplifies challenging bone grafting and soft tissue regeneration.
  • Acts directly on stem cells.
  • Induces bone regeneration without infection in extraction socket.
  • Contains 1 mg of bone morphogenic protein per 1g of the particle (1g of autologous bone contains 2ng of
    bone morphogenic protein).


A. Orthopedics
Bone grafts
  • Fractures : Tibia, Radius, Ulna
  • Spine Fusion (Degenerative Disc Disease)
    : Interbody cage, Posteolateral
Injection Device
  • Lengthening : Distraction osteogenesis
  • Osteoporosis : Hip joint fracture
  • Bone Defect : Bone cyst
  • Bone Fusion : Foot/shoulder revision
B. Dentistry
Bone grafts
  • Severely resorbed alveolar ridges
  • Tooth extraction socket
  • Alveolar bone loss
  • Maxillary sinus bone loss
  • Bone-inductive implant : Coted implant
  • Maxillofacial reconstruction
C. Dermatology
Soft Tissue Grafts
  • Damaged skin regeneration
  • Diabetes ulcer

Mechanism of Action of COWELL® BMP

Migration of Cells with lamellipodia
Cellular mechanisms
  • BMP-2 adheres to the membrane of stem cell and induces expression of
    genes of nucleus. Then, BMP-2 migrates to recipient site.
  • BMP-2 growth factor, Twist-2 transcriptional factor, and VEGF growth
    factor synthesize and secrete endogenous growth factor.
  • Proliferation of osteoblast of osteocyte, and proliferation of fibroblast in dermis
    and keratinocyte of the skin.
  • Twist-2 transcriptional factor induces tissue regeneration in osseous tissue
    and adherent gingival area.

Product Type

COWELL® BMP (One vial)
  • Dose and particle size of COWELL® BMP

* A vial of 0.1g can be used for less than one extraction socket, while 0.25g/0.5g can be used for maxillary sinus or for the wide bone defect area.

COWELL® BMP Plus (Two vials)
  • Dose and Particle Size of COWELL® BMP
INNO GF Kit(Two vials + Saline solution + Syringe)
  • Dose and Particle Size of INNO GF Kit

User Guide of COWELL® BMP

Method I
  • Transfer BCP graft material (Vial I).

  • Inject distilled water into vial II with lyophilized
    rhBMP-2 power in it and mix with the powder.

  • Mix BMP solution with BCP or plus autogenic
    / allograft and apply into the recipient site.

  • Cover the defect area using a barrier membrane
    or suture natural soft tissue without membrane.

Method II
  • Transfer BCP graft material
    (Vial I) into a container.

  • Apply BCP into the recipient site and cover
    the defect area using a barrier membrane
    or suture natural soft tissue without membrane.

  • Inject distilled water into lyophilized
    rhBMP-2 powder (vial II).

  • Mix rhBMP-2 with distilled water (saline
    solution) and wait for 10 ~ 15 mintues
    before using.

  • Aspirate the mixture using a syringe.

  • Inject BMP solution through soft tissue
    until needle of syringe reaches bone.

Method III
  • Inject distilled water into vial II with lyophilized
    rhBMP-2 power in it and mix with the powder.

  • Aspirate the mixture using a syringe.

  • Hydrate BMP-2 solution into membrane.

  • Apply BMP-2 solution socked membrane
    to damaged site.

Dose of distilled water to make the mixture (BMP-2 Solution)
BMP Dose Distilled Water Dose BMP Dose Distilled Water Dose
0.1mg 0.1ml 2mg 1.6ml
0.25mg 0.2ml 5mg 4ml
0.5mg 0.4ml 10mg 8ml
1mg 0.8ml 20mg 16ml

Study Result on COWELL® BMP Bone Graft

In vivo Study
Jung-Bo Huh, et al., Alveolar ridge augmentation using anodized implants coated with Escherichia coli-derived recombinant
human bone morphogenetic protein 2 (Beagle dog)

- Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 -

Histologic Findings
: Tissue specimen collected approximately four months after the maxillary sinus grafting

  • New bone was formed around the graft material.
  • No inflammatory reaction was observed in connective tissue.
  • Proliferation of collagen fiber was observed.
  • Proliferation of fibrocyte was observed.
  • Osteoblast was observed on the surface of newly formed bone.

Clinical Data of COWELL® BMP Bone Graft

- Vertical height of surrounding bone was compared three months after grafting in extraction socket.
The study was conducted at Seoul National University Bundang Hospital, Yonsei University Dental Hospital, and Korea University Guro Hospital.

Clinical Data of COWELL BMP Bone Graft
Group Average SD 95%CI †P value
Height Control -1.087 1.413 (-1.565, -0.609) 0.0006**
Experiment -0.059 0.960 (-0.384, -0.266)
Width at 75% ESL Control 1.405 1.753 (0.812, 1.998) 0.346
Experiment 1.863 2.310 (1.081, 2.644)
Width at 50% ESL Control 0.542 1.157 (0.15, 0.934) 0.016*
Experiment 1.239 1.249 (0.816, 1.662)
Width at 25% ESL Control 0.006 1.149 (-0.383, 0.395) <0.0001**
Experiment 1.279 1.387 (0.81, 1.749)

SL : Extraction Socket Level                 *:P<.05, **:P<.01, †: Student t-test

Jung-Bo Huh, et al., Multicenter, randomized clinical trial on the efficacy and safety of Escherichia-coli-derived rhBMP-2
with β-Tricalcium phosphate and hydroxyapatite in human extraction sockets

- J Adv Prosthodont 2011;4 -134.

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